Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic
strategy for various age-related diseases. Most senolytics target antiapoptotic proteins …

Aging is the most important single risk factor for many chronic diseases such as cancer,
metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might …

Senescent cells accumulate with aging and at etiological sites of multiple diseases,
including those accounting for most morbidity, mortality, and health costs. Senescent cells …

Cellular senescence, a stable cell division arrest caused by severe damage and stress, is a
hallmark of aging in vertebrates including humans. With progressing age, senescent cells …

Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

Although the clearance of senescent cells has been proven to slow down the aging process
and promote anti‐cancer chemotherapy, the development of senolytics remains challenging …

The accumulation of senescent cells is associated with aging, inflammation and cellular
dysfunction. Senolytic drugs can alleviate age-related comorbidities by selectively killing …

Senescence is a cellular state characterized by its near-permanent halted cell cycle and
distinct secretory phenotype. Although senescent cells have a variety of beneficial …

Aging is defined as a progressive decrease in physiological function accompanied by a
steady increase in mortality. The antagonistic pleiotropy theory proposes that aging is …