Decreasing glucagon action lowers the blood glucose and may be useful therapeutically for
diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify …

Understanding the regulation of islet cell mass has important implications for the discovery
of regenerative therapies for diabetes. The liver plays a central role in metabolism and the …

Glucagon secreted from the pancreatic alpha-cells is essential for regulation of blood
glucose levels. However, glucagon may play an equally important role in the regulation of …

Glucagon and its partner insulin are dually linked in both their secretion from islet cells and
their action in the liver. Glucagon signaling increases hepatic glucose output, and …

Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by
promoting the uptake and conversion of amino acids into gluconeogenic precursors. Genetic …

Objective Glucagon is well known to regulate blood glucose but may be equally important
for amino acid metabolism. Plasma levels of amino acids are regulated by glucagon …

The aim of this study was to identify the amino acids that stimulate glucagon secretion in
mice and whose metabolism depends on glucagon receptor signaling. Pancreata of female …

Aims/hypothesis The secretion of glucagon is controlled by blood glucose and inappropriate
secretion of glucagon contributes to hyperglycaemia in diabetes. Besides its role in glucose …

Type 2 diabetes mellitus (T2DM) results from insulin resistance and β-cell dysfunction, in the
setting of hyperglucagonemia. Glucagon is a 29 amino acid peptide hormone, which is …

Objective While the molecular events controlling insulin secretion from β-cells have been
documented in detail, the exact mechanisms governing glucagon release by α-cells are …