Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention
GK Hagos, SO Abdul-Hay, J Sohn, PD Edirisinghe… - Molecular …, 2008 - ASPET
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown promise in colorectal cancer
(CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates …
(CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates …
Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo
GK Hagos, RE Carroll, T Kouznetsova, Q Li… - Molecular cancer …, 2007 - AACR
Chemopreventive agents in colorectal cancer possess either antiproliferative or anti-
inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 …
inflammatory actions. Nonsteroidal anti-inflammatory drugs (NSAID) and cyclooxygenase-2 …
NO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action
B Rigas, JL Williams - Nitric Oxide, 2008 - Elsevier
Nitric oxide-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs) consist of a
conventional NSAID to which an NO-releasing moiety is attached covalently, often via a …
conventional NSAID to which an NO-releasing moiety is attached covalently, often via a …
Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality
T Dunlap, SO Abdul-Hay, REP Chandrasena… - Nitric Oxide, 2008 - Elsevier
Properties of the NO-ASA family of NO-donating NSAIDs (NO-NSAIDs), notably NCX 4016
(mNO-ASA) and NCX 4040 (pNO-ASA), reported in more than one hundred publications …
(mNO-ASA) and NCX 4040 (pNO-ASA), reported in more than one hundred publications …
Development of novel agents based on nitric oxide for the control of colon cancer1
V Kozoni, T Rosenberg, B Rigas - Acta Pharmacologica Sinica, 2007 - Wiley Online Library
Nitric oxide‐donating nonsteroidal anti‐inflammatory drugs (NO‐NSAIDs) represent a novel
class of compounds that hold promise as agents for the control of colon cancer. They are …
class of compounds that hold promise as agents for the control of colon cancer. They are …
Novel agents for cancer prevention based on nitric oxide
B Rigas - Biochemical Society Transactions, 2007 - portlandpress.com
NO (nitric oxide) biology has provided the impetus for the development of anticancer agents
based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti …
based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti …
Efficacy of a nitric oxide–releasing nonsteroidal anti-inflammatory drug and cytotoxic drugs in human colon cancer cell lines in vitro and xenografts
C Leonetti, M Scarsella, G Zupi, W Zoli… - Molecular cancer …, 2006 - AACR
We previously showed that NCX 4040 inhibits in vitro and in vivo tumor growth and induces
apoptosis in human colon cancer cell lines. On the basis of these results, NCX 4040 …
apoptosis in human colon cancer cell lines. On the basis of these results, NCX 4040 …
Nitric oxide-releasing non steroidal anti-inflammatory drugs: a new generation of anti-tumoral molecules
C Lavagna, PD Soldato, JL Burgaud… - Current Cancer Drug …, 2003 - ingentaconnect.com
Colorectal cancer is the second most common cause of cancer-related mortality in the west.
The high incidence and mortality make effective prevention an important public-health and …
The high incidence and mortality make effective prevention an important public-health and …
GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway
SS Pathi, I Jutooru, G Chadalapaka, S Sreevalsan… - Molecular Cancer …, 2011 - AACR
Abstract Ethyl 2-((2, 3-bis (nitrooxy) propyl) disulfanyl) benzoate (GT-094) is a novel nitric
oxide (NO) chimera containing an nonsteroidal anti-inflammatory drug (NSAID) and NO …
oxide (NO) chimera containing an nonsteroidal anti-inflammatory drug (NSAID) and NO …
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs …
JL Williams, S Borgo, I Hasan, E Castillo, F Traganos… - Cancer Research, 2001 - AACR
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …