Mismatch repair (MMR) system maintains genome integrity by correcting mispaired or
unpaired bases which have escaped the proofreading activity of DNA polymerases. The …

Mismatch repair (MMR) systems are central to maintaining genome stability in prokaryotes
and eukaryotes. MMR proteins play a fundamental role in avoiding mutations, primarily by …

Mismatch repair (MMR) proteins play a critical role in maintaining the mitotic stability of
eukaryotic genomes. MMR proteins repair errors made during DNA replication and in their …

A problem in understanding eukaryotic DNA mismatch repair (MMR) mechanisms is linking
insights into MMR mechanisms from genetics and cell-biology studies with those from …

▪ Abstract DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects
mismatches generated during DNA replication and escape proofreading. MMR proteins also …

The molecular mechanisms of the DNA mismatch repair (MMR) system have been
uncovered over the last decade, especially in prokaryotes. The results obtained for …

DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA
replication errors. The fundamental mechanisms and proteins involved in the early reactions …

Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric
complexes of MutS-related proteins: MSH2–MSH3 and MSH2–MSH6. These two complexes …

How can the activities of differ-ent proteins that act at two distant sites on DNA be coupled?
In cis mechanisms, an intact DNA helix is required so that the protein molecules can slide …

The genome of all organisms is constantly being challenged by endogenous and
exogenous sources of DNA damage. Errors like base: base mismatches or small insertions …