ALZHEIMER'S disease is the most common cause of progressive intellectual failure1. The
lesions that develop, called senile plaques, are extracellular deposits principally composed …

The role of non-neuronal cells in Alzheimer's disease progression has not been fully
elucidated. Using single-nucleus RNA sequencing, we identified a population of disease …

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer's disease
(AD). Previous evidence suggested disruptions of multiple stages of the autophagy …

Alzheimer's disease constitutes a rising threat to public health. Despite extensive research in
cellular and animal models, identifying the pathogenic agent present in the human brain and …

Reactive astrocytes are strongly induced by central nervous system (CNS) injury and
disease, but their role is poorly understood. Here we show that a subtype of reactive …

In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia
processes, but the significance of this phenomenon is unknown. Here we show that …

Cognitive decline remains an unaddressed problem for the elderly. We show that
myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with …

Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

During recent years, the preclinical stage of Alzheimer's disease (AD) has become a major
focus of research. Continued failures in clinical trials and the realization that early …