The neurodegenerative disorder Alzheimer's disease is becoming more prevalent in ageing
populations worldwide. The identification of effective treatments will require a better …

Despite tremendous investments in understanding the complex molecular mechanisms
underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A …

Recent human trials of treatments for Alzheimer's disease (AD) have been largely
unsuccessful, raising the idea that treatment may need to be started earlier in the disease …

In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these
cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed …

Complex diseases are characterized by spatiotemporal cellular and molecular changes that
may be difficult to comprehensively capture. However, understanding the spatiotemporal …

Alzheimer disease is the most common cause of dementia. According to the World Health
Organization, an estimated 37 million people worldwide currently have dementia; Alzheimer …

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia
contribute to Aβ propagation into unaffected brain regions remains unknown. Using …

A PATHOLOGICALhallmark of Alzheimer's disease is the senile plaque, containing β-
amyloid fibrils, microglia and astrocytes1. β-amyloid fibrils exert a cytotoxic effect on …

Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all …

Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and
intracellular tau inclusions. However, the exact mechanistic link between these two AD …