Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects a large
proportion of the elderly population. Amyloid plaques, which are a neuro-pathological …

The detection of myelin disruptions in Alzheimer's disease (AD)–affected brain raises the
possibility that oligodendrocytes undergo pathophysiological assault over the protracted …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by
amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells …

Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its
course is heterogeneous, with a broad range of rates of cognitive decline. The spread of tau …

Microglia maintain homeostasis in the central nervous system through phagocytic clearance
of protein aggregates and cellular debris. This function deteriorates during ageing and …

Alzheimer's disease is characterized by the accumulation of amyloid-beta in plaques,
aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation …

Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …

The global epidemic of Alzheimer disease (AD) is worsening, and no approved treatment
can revert or arrest progression of this disease. AD pathology is characterized by the …

To clarify the role of microglia in brain homeostasis and disease, an understanding of their
maintenance, proliferation and turnover is essential. The lifespan of brain microglia …

Microglia, the tissue-resident macrophages in the brain, are damage sensors that react to
nearly any perturbation, including neurodegenerative diseases such as Alzheimer's disease …