[HTML][HTML] Current and future direction in treatment of HPV-related cervical disease
N Khairkhah, A Bolhassani, R Najafipour - Journal of Molecular Medicine, 2022 - Springer
Human papillomavirus (HPV) is the most common sexually transmitted virus in the world.
About 70% of cervical cancers are caused by the most oncogenic HPV genotypes of 16 and …
About 70% of cervical cancers are caused by the most oncogenic HPV genotypes of 16 and …
Disruption of HPV16‐E7 by CRISPR/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells
High‐risk human papillomavirus (HR‐HPV) has been recognized as a major causative
agent for cervical cancer. Upon HPV infection, early genes E6 and E7 play important roles in …
agent for cervical cancer. Upon HPV infection, early genes E6 and E7 play important roles in …
[HTML][HTML] CRISPR/Cas9-mediated cervical cancer treatment targeting human papillomavirus E6
T Yoshiba, Y Saga, M Urabe, R Uchibori… - Oncology …, 2019 - spandidos-publications.com
High-risk human papillomavirus (HPV) is a common cause of cervical cancer. HPV E6
oncoprotein promotes the degradation of host tumor suppressor gene p53, leading to the …
oncoprotein promotes the degradation of host tumor suppressor gene p53, leading to the …
Delivery of genome editing tools: A promising strategy for HPV-related cervical malignancy therapy
Introduction Persistent high-risk human papillomavirus infection is the main cause of various
types of cancer especially cervical cancer. The E6 and E7 oncoproteins of HPV play critical …
types of cancer especially cervical cancer. The E6 and E7 oncoproteins of HPV play critical …
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system
Y Chen, H Jiang, T Wang, D He, R Tian, Z Cui, X Tian… - Antiviral Research, 2020 - Elsevier
Sustained infection of high-risk human papillomavirus (HR-HPVs), especially HPV16 and
HPV18, is a major cause of cervical cancer. E6 and E7 oncoproteins, encoded by the HPV …
HPV18, is a major cause of cervical cancer. E6 and E7 oncoproteins, encoded by the HPV …
Oncogenic human papillomavirus: application of CRISPR/Cas9 therapeutic strategies for cervical cancer
S Zhen, X Li - Cellular Physiology and Biochemistry, 2018 - karger.com
Oncogenic human papillomaviruses (HPVs) cause different types of cancer especially
cervical cancer. HPV-associated carcinogenesis provides a classical model system for …
cervical cancer. HPV-associated carcinogenesis provides a classical model system for …
In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9
S Zhen, L Hua, Y Takahashi, S Narita, YH Liu… - … and biophysical research …, 2014 - Elsevier
Deregulated expression of high-risk human papillomavirus oncogenes (E6 and E7) is a
pivotal event for pathogenesis and progression in cervical cancer. Both viral oncogenes are …
pivotal event for pathogenesis and progression in cervical cancer. Both viral oncogenes are …
[HTML][HTML] The application of CRISPR/Cas9 system in cervical carcinogenesis
C Gao, P Wu, L Yu, L Liu, H Liu, X Tan, L Wang… - Cancer Gene …, 2022 - nature.com
Integration of high-risk HPV genomes into cellular chromatin has been confirmed to promote
cervical carcinogenesis, with HPV16 being the most prevalent high-risk type. Herein, we …
cervical carcinogenesis, with HPV16 being the most prevalent high-risk type. Herein, we …
[HTML][HTML] Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells
R Tian, J Liu, W Fan, R Li, Z Cui, Z Jin, Z Huang… - Molecular Therapy …, 2022 - cell.com
A genome editing tool targeting the high-risk human papillomavirus (HPV) oncogene is a
promising therapeutic strategy to treat HPV-related cervical cancer. To improve gene …
promising therapeutic strategy to treat HPV-related cervical cancer. To improve gene …
[HTML][HTML] Reprogrammed CRISPR-Cas9 targeting the conserved regions of HPV6/11 E7 genes inhibits proliferation and induces apoptosis in E7-transformed …
YC Liu, ZM Cai, XJ Zhang - Asian journal of andrology, 2016 - journals.lww.com
The persistence infection of low-risk type (type 6 or type 11) of human papillomavirus (HPV)
is the main cause of genital warts. Given the high rate of recurrence after treatment, the use …
is the main cause of genital warts. Given the high rate of recurrence after treatment, the use …