Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

The discovery and interpretation of peroxisome proliferator-activated receptor γ coactivator
1α (PGC-1α) protein in mitochondrial biogenesis, skeletal muscle and adipose tissue …

Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps
best known as a master regulator of mitochondrial biogenesis and function. However, by …

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-
1β (PGC-1β) has been implicated in important metabolic processes. A mouse lacking PGC …

Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of
the mitochondria and biosynthetic pathways as well. PPARγ coactivator 1α (PGC1α) is a key …

Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Aging is the progressive decline in cellular, tissue, and organ function. This complex process
often manifests as loss of muscular strength, cardiovascular function, and cognitive ability …

Mitochondrial dysfunction results in high levels of oxidative stress and mitochondrial
damage, leading to disruption of endothelial homeostasis. Recent discoveries have clarified …

PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in
cells. Recent work highlighted that PGC1α can also modulate the composition and functions …

PGC1α acts as a central regulator of mitochondrial metabolism, whose role in cancer
progression has been highlighted but remains largely undefined. Especially, it is completely …