Recent studies suggest a potential role for 5-hydroxytryptamine6 (5-HT6) receptors in the
regulation of addictive behavior. In the present study, our aim was to investigate whether the …

5-HT6 receptors are almost exclusively expressed in the central nervous system, particularly
in areas relevant for addictive behaviour. Based on this, together with other data, this …

The endogenous brain serotonin (5-HT) system is believed to have an important modulatory
influence in mediating drug reward and seeking mechanisms. Data from preclinical …

Alcohol and drug abuse take a large toll on society and affected individuals. However, very
few effective treatments are currently available to treat alcohol and drug addiction. Basic and …

Re-exposure to drug-related cues elicits drug-seeking behaviour and relapse in humans
even after months of abstinence. Similarly, in laboratory rats, drug-associated stimuli …

Abstract The ionotropic serotonin subtype-3 (5-HT 3) receptor has emerged as a potential
therapeutic target in the treatment of alcohol abuse and alcoholism because selective …

Serotonin systems have been implicated in incentive motivation for cocaine, yet little is
known about the role of 5-HT1B receptors in these processes. We used the extinction …

The localization of serotonin 5-HT6 receptors in limbic and motor brain regions, and the high
affinity of these receptors for several antipsychotic agents, suggest that they may be involved …

Extensive studies have ascribed a role for the central 5-HT 3 receptor in the modulation of
behaviour. Much of the work stems from the actions of potent and selective 5-HT 3 receptor …

Ethanol sensitivity may play a role in the risk of developing alcoholism. The role of 5-HT 3
receptors in sensitivity to ethanol was assessed in mice over-expressing the 5-HT 3 receptor …