Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …

Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of
autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and …

The type I interferon (IFN) system is our main defense against viral infections and consists of
a large number of sensors of nucleic acid that can trigger the production of more than 15 …

Abstract Type I interferons (IFN-Is) are a group of molecules with pleiotropic effects on the
immune system forming a crucial link between innate and adaptive immune responses …

Increased blood levels of type I interferon (IFN-I) and expression of a broad signature of
gene transcripts that reflect induction by IFN-I are observed in many patients with systemic …

Type I and type III interferons (IFNs) share several properties in common, including the
induction of signaling pathways, the activation of gene transcripts, and immune responses …

Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …

Type I interferons (IFNs) play essential roles in establishing and modulating host defense
against microbial infection via induction of IFN-stimulated genes (ISGs) through Janus …

Several lines of evidence strongly implicate type I interferons (IFN-α and β) and IFN-
signaling in the pathogenesis of certain autoimmune inflammatory diseases. Accordingly …

Many patients with systemic autoimmune diseases have signs of a continuous production of
type I interferon (IFN) and display an increased expression of IFN-α-regulated genes. The …