One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of
molecular biology and the new tools derived from molecular genetics have revolutionized …

Pharmacological, surgical, psychological, and alternative medicine approaches for the
treatment of chronic pain, including neuropathic pain, provide only partial relief for most …

Like many other complex biological phenomena, pain is starting to be studied at the level of
the gene. Advances in molecular biological technology have allowed the cloning, mapping …

The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of
the rapidly developing field of pain research. As populations age, the number of people in …

The transgenic knockout mouse is one of the most important tools of modern biology, and
commonly employed by pain researchers to examine the function of genes of interest. Over …

Pain, which afflicts up to 20% of the population at any time, provides both a massive
therapeutic challenge and a route to understanding mechanisms in the nervous system …

The molecular/genetic era has seen the discovery of a staggering number of molecules
implicated in pain mechanisms [18],[35],[61],[69],[96],[133],[150],[202],[224]. This has …

Human pain causes untold misery and suffering, with major impact on functioning and
resources. Recent advances in genetics have revealed that subtle changes in DNA could …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

The application of transgenic (knockout) technology to the study of pain is rapidly
expanding. Despite its power, this technique has several shortcomings that complicate the …