[HTML][HTML] Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids
Z Zang, H Yin, Z Du, R Xie, L Yang, Y Cai… - Frontiers in Molecular …, 2022 - frontiersin.org
Valproic acid (VPA) exposure during pregnancy leads to a higher risk of autism spectrum
disorder (ASD) susceptibility in offspring. Human dorsal forebrain organoids were used to …
disorder (ASD) susceptibility in offspring. Human dorsal forebrain organoids were used to …
[HTML][HTML] Human forebrain organoids reveal connections between valproic acid exposure and autism risk
Q Meng, W Zhang, X Wang, C Jiao, S Xu, C Liu… - Translational …, 2022 - nature.com
Valproic acid (VPA) exposure as an environmental factor that confers risk of autism spectrum
disorder (ASD), its functional mechanisms in the human brain remain unclear since relevant …
disorder (ASD), its functional mechanisms in the human brain remain unclear since relevant …
[HTML][HTML] Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model
Prenatal exposure to environmental insults can increase the risk of developing
neurodevelopmental disorders. Administration of the antiepileptic drug valproic acid (VPA) …
neurodevelopmental disorders. Administration of the antiepileptic drug valproic acid (VPA) …
[HTML][HTML] Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates
H Zhao, Q Wang, T Yan, Y Zhang, H Xu, H Yu… - Translational …, 2019 - nature.com
Despite the substantial progress made in identifying genetic defects in autism spectrum
disorder (ASD), the etiology for majority of ASD individuals remains elusive. Maternal …
disorder (ASD), the etiology for majority of ASD individuals remains elusive. Maternal …
[HTML][HTML] The proliferation of dentate gyrus progenitors in the ferret hippocampus by neonatal exposure to valproic acid
Prenatal and neonatal exposure to valproic acid (VPA) is associated with human autism
spectrum disorder (ASD) and can alter the development of several brain regions, such as …
spectrum disorder (ASD) and can alter the development of several brain regions, such as …
[HTML][HTML] Distinct defects in synaptic differentiation of neocortical neurons in response to prenatal valproate exposure
Y Iijima, K Behr, T Iijima, B Biemans, J Bischofberger… - Scientific reports, 2016 - nature.com
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders characterized by impairments in social interactions and stereotyped behaviors …
disorders characterized by impairments in social interactions and stereotyped behaviors …
Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin …
HS Go, KC Kim, CS Choi, SJ Jeon, KJ Kwon, SH Han… - …, 2012 - Elsevier
Autism is a spectrum of neurodevelopmental disorders characterized by social isolation and
lack of interaction. Anatomically, autism patients often show macrocephaly and high …
lack of interaction. Anatomically, autism patients often show macrocephaly and high …
[HTML][HTML] In utero exposure to valproic acid throughout pregnancy causes phenotypes of autism in offspring mice
Valproic acid (VPA) is an antiepileptic drug that inhibits the epileptic activity of neurons
mainly by inhibiting sodium channels and GABA transaminase. VPA is also known to inhibit …
mainly by inhibiting sodium channels and GABA transaminase. VPA is also known to inhibit …
In utero exposure to valproic acid induces neocortical dysgenesis via dysregulation of neural progenitor cell proliferation/differentiation
K Fujimura, T Mitsuhashi, S Shibata… - Journal of …, 2016 - Soc Neuroscience
Valproic acid (VPA), a widely used antiepileptic drug, is an inhibitor of histone deacetylases,
which epigenetically modify cell proliferation/differentiation in developing tissues. A series of …
which epigenetically modify cell proliferation/differentiation in developing tissues. A series of …
[HTML][HTML] Valproic acid-exposed astrocytes impair inhibitory synapse formation and function
K Takeda, T Watanabe, K Oyabu, S Tsukamoto… - Scientific Reports, 2021 - nature.com
Valproic acid (VPA) is widely prescribed to treat epilepsy. Maternal VPA use is, however,
clinically restricted because of the severe risk that VPA may cause neurodevelopmental …
clinically restricted because of the severe risk that VPA may cause neurodevelopmental …