[HTML][HTML] PLX5622 reduces disease severity in lethal CNS infection by off-target inhibition of peripheral inflammatory monocyte production
PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate
the biology of this central nervous system (CNS)-resident myeloid population, but the …
the biology of this central nervous system (CNS)-resident myeloid population, but the …
[HTML][HTML] CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis
Background Microglia are resident macrophages of the central nervous system (CNS)
locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling. Microglial …
locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling. Microglial …
Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
DR Getts, RL Terry, MT Getts, M Müller… - The Journal of …, 2008 - rupress.org
In a lethal West Nile virus (WNV) model, central nervous system infection triggered a
threefold increase in CD45int/CD11b+/CD11c− microglia at days 6–7 postinfection (pi). Few …
threefold increase in CD45int/CD11b+/CD11c− microglia at days 6–7 postinfection (pi). Few …
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system
The present study examines functional contributions of microglia in host defense,
demyelination, and remyelination following infection of susceptible mice with a neurotropic …
demyelination, and remyelination following infection of susceptible mice with a neurotropic …
[HTML][HTML] Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
Microglia, the primary immune cells of the central nervous system (CNS), are derived from
the yolk sac and populate the brain during development. Once microglia migrate to the CNS …
the yolk sac and populate the brain during development. Once microglia migrate to the CNS …
[HTML][HTML] High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease
AG Spiteri, RL Terry, CL Wishart, TM Ashhurst… - Journal of …, 2021 - Springer
Background Differentiating infiltrating myeloid cells from resident microglia in
neuroinflammatory disease is challenging, because bone marrow-derived inflammatory …
neuroinflammatory disease is challenging, because bone marrow-derived inflammatory …
[HTML][HTML] Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation
W Claeys, D Verhaege, G Van Imschoot… - Frontiers in …, 2023 - frontiersin.org
Microglia, the resident macrophages of the central nervous system (CNS), play a critical role
in CNS homeostasis and neuroinflammation. Pexidartinib (PLX3397), a colony-stimulating …
in CNS homeostasis and neuroinflammation. Pexidartinib (PLX3397), a colony-stimulating …
[HTML][HTML] Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945
N Beckmann, E Giorgetti, A Neuhaus… - Acta neuropathologica …, 2018 - Springer
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous
system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they …
system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they …
[HTML][HTML] Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection
AG Spiteri, CL Wishart, D Ni, B Viengkhou… - Acta Neuropathologica …, 2023 - Springer
As the resident parenchymal myeloid population in the central nervous system (CNS),
microglia are strategically positioned to respond to neurotropic virus invasion and have …
microglia are strategically positioned to respond to neurotropic virus invasion and have …
[HTML][HTML] GM-CSF is not essential for experimental autoimmune encephalomyelitis but promotes brain-targeted disease
ER Pierson, JM Goverman - JCI insight, 2017 - ncbi.nlm.nih.gov
Experimental autoimmune encephalomyelitis (EAE) has been used as an animal model of
multiple sclerosis to identify pathogenic cytokines that could be therapeutic targets …
multiple sclerosis to identify pathogenic cytokines that could be therapeutic targets …