For a long time, lysosomes were considered merely to be cellular'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …

Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Recent evidence indicates that the importance of the lysosome in cell metabolism and
organism physiology goes far beyond the simple disposal of cellular garbage. This dynamic …

This review focuses on the pathways that regulate lysosome biogenesis and that are
implicated in numerous degenerative storage diseases, including lysosomal storage …

The lysosome is the main catabolic hub of the cell. Owing to its role in fundamental
processes such as autophagy, plasma membrane repair, mTOR signaling, and maintenance …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance
and energy production to respond to environmental cues. However, the mechanisms …

The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …

Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of …

Lysosomes are membrane-bound organelles found in every eukaryotic cell. They are widely
known as terminal catabolic stations that rid cells of waste products and scavenge metabolic …