The inflammatory response following particle inhalation is described as a key event in the
development of lung diseases, eg, fibrosis and cancer. The essential role of alveolar …

Background Inhalation of crystalline silica induces a pulmonary fibrotic degeneration called
silicosis caused by the inability of alveolar macrophages to dissolve the crystalline structure …

The uptake of respirable quartz particles by alveolar macrophages (AM) is believed to cause
an inflammatory response, which is discussed as a crucial step in quartz pathogenicity …

Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the
inflammatory response to inhaled particles. The present study aims at the time course of …

Bronchial epithelial cells are the first barrier of defense against respiratory pathogens. Dust
particles as extracellular stimuli are associated with inflammatory reactions after inhalation. It …

Inhalation of quartz particles is associated with a variety of adverse lung effects. Since
particle surface is considered to be crucial for particle pathogenicity, we investigated the …

The A549 cell line was used to model in vitro the interaction of alveolar epithelium with
environmental particulates. Confocal and electron microscopy demonstrated A549 binding …

Chronic beryllium disease (CBD) is a metal hypersensitivity/autoimmune disease in which
damage-associated molecular patterns (DAMPs) promote a break in T cell tolerance and …

Inhalation of (nano) particles may lead to pulmonary inflammation. However, the precise
mechanisms of particle uptake and generation of inflammatory mediators by alveolar …

Bovine alveolar macrophages were exposed in vitro to quartz dusts, metal-containing dusts
or silica particles coated with a single metal oxide. The release of reactive oxygen …