Isoprostane generation and function

GL Milne, H Yin, KD Hardy, SS Davies… - Chemical …, 2011 - ACS Publications
Free radicals derived primarily from molecular oxygen have been implicated in a variety of
human disorders including atherosclerosis, cancer, neurodegenerative diseases, and aging …

The isoprostanes—25 years later

GL Milne, Q Dai, LJ Roberts II - … et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the
cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first …

Human biochemistry of the isoprostane pathway

GL Milne, H Yin, JD Morrow - Journal of Biological Chemistry, 2008 - ASBMB
Free radicals derived primarily from molecular oxygen have been implicated in a variety of
human disorders including atherosclerosis, cancer, neurodegenerative diseases, and aging …

Recent advances in the biochemistry and clinical relevance of the isoprostane pathway

ES Musiek, H Yin, GL Milne, JD Morrow - Lipids, 2005 - Wiley Online Library
Isoprostanes (IsoPs), lipid peroxidation products formed via the free radical‐mediated
oxidation of arachidonic acid, have become the “gold standard” biomarker of oxidative stress …

Isoprostanes

LJ Roberts, GL Milne - Journal of lipid research, 2009 - ASBMB
The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in
vivo via a nonenzymatic mechanism involving the free radical-initiated peroxidation of …

Factors Regulating Isoprostane Formation In Vivo

S Basu, J Helmersson - Antioxidants & redox signaling, 2005 - liebertpub.com
Discovery of the F2-isoprostanes, a group of prostaglandin F2α-like compounds
biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel …

F2-Isoprostanes in Human Health and Diseases: From Molecular Mechanisms to Clinical Implications

S Basu - Antioxidants & redox signaling, 2008 - liebertpub.com
Oxidative stress is implicated as one of the major underlying mechanisms behind many
acute and chronic diseases, and involved in normal aging. However, the measurement of …

The isoprostanes-unique products of arachidonate peroxidation: their role as mediators of oxidant stress

JD Morrow - Current Pharmaceutical Design, 2006 - ingentaconnect.com
The isoprostanes (IsoPs) are a series of novel prostaglandin-like compounds formed in vivo
in humans from the free radical-catalyzed peroxidation of arachidonate independent of the …

The isoprostanes: novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid

T Liu, A Stern, LJ Roberts, JD Morrow - Journal of biomedical science, 1999 - Springer
The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in
vivo from the free radical-catalyzed peroxidation of arachidonic acid. This review …

F2-Isoprostanes as markers of oxidative stress in vivo: An overview

GL Milne, ES Musiek, JD Morrow - Biomarkers, 2005 - Taylor & Francis
The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a
non-enzymatic mechanism involving the free radical-initiated peroxidation of arachidonic …