Taxol is the first-line drug for cancer treatment. However, tumor resistance to Taxol is still a
significant challenge in clinical practice. Here, we studied the synergistic effect of a …

Two Ru (II) polypyridyl complexes [Ru (bpy) 2 (pztp)] 2+(Ru1) and [Ru (bpy) 2 (pytp)]
2+(Ru2) were synthesized and characterized. Our data demonstrated that Ru2 displayed …

Ruthenium complexes are expected to be new opportunities for the development of
antitumor agents. Herein, four ruthenium polypyridyl complexes ([Ru (bpy) 2 (CAPIP)](ClO 4) …

Aquation has been proposed as crucial chemical action step for ruthenium (Ru) complexes,
but its effects on the action mechanisms remain elusive. Herein, we have demonstrated the …

Ruthenium (Ru) polypyridyl complexes have emerged as leading players among the
potential metal-based candidates for cancer treatment. However, the roles of cellular …

Ruthenium-containing complexes have emerged as good alternative to the currently used
platinum-containing drugs for malignant tumor therapy. In this work, cytotoxic effects of …

Ruthenium (II/III) metal complexes have been widely recognized as the alternative
chemotherapeutic agents to overcome the drug resistance and tumor recurrence associated …

TrxR is an NADPH-dependent selenoenzyme upregulated in a number of cancers. It plays a
pivotal role in cancer progression and represents an increasingly attractive target for …

In this article, four new Ru (II) complexes [Ru (dmbpy) 2 (TFBIP)](PF 6) 2 (dmbpy= 4, 4′-
dimethyl-2, 2′-bipyridine, TFPIP= 2-(4′-trifluoromethyl)-[1, 1′-biphenyl]-4-yl)-1H-imidazo …

Herein, ruthenium complexes containing heterocyclic thioamidates [Ru (mmi)(bipy)(dppb)]
PF6 (1),[Ru (tzdt)(bipy)(dppb)] PF6 (2),[Ru (dmp)(bipy)(dppb)] PF6 (3) and [Ru …