NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which
causes human African trypanosomiasis. Optimized with phenotypic screening, targets of …

Hypothetical proteins can provide an alternative pathway for finding potential targets in the
development of new drugs due to the fact that many Neglected tropical diseases are caused …

African trypanosomes cause lethal and neglected tropical diseases, known as sleeping
sickness in humans and nagana in animals. Current therapies are limited, but fortunately …

CBL0137 is a lead drug for human African trypanosomiasis, caused by Trypanosoma brucei.
Herein, we use a four-step strategy to 1) identify physiologic targets and 2) determine modes …

Chemotherapy continues to have a major impact on reducing the burden of disease caused
by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of antitrypanosomal …

Background Trypanosoma cruzi is a Kinetoplastid parasite of humans and is the cause of
Chagas disease, a potentially lethal condition affecting the cardiovascular, gastrointestinal …

Trypanosoma brucei causes human African trypanosomiasis (HAT). The pyrrolopyrimidine
AEE788 (a hit for anti-HAT drug discovery) associates with three trypanosome protein …

Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in
African Trypanosomes Page 1 CORRECTION Correction: Modulation of the Surface …

Human African trypanosomiasis is a neglected tropical disease that is lethal if left untreated.
Existing therapeutics have limited efficacy and severe associated toxicities. 2-(2-(((3-((1 H …

The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping
sickness, and there is an urgent unmet need for improved treatments. Parasite protein …