Cell-penetrating peptides: design, synthesis, and applications

DM Copolovici, K Langel, E Eriste, U Langel - ACS nano, 2014 - ACS Publications
The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Cell-penetrating peptides as delivery vehicles for biology and medicine

KM Stewart, KL Horton, SO Kelley - Organic & biomolecular chemistry, 2008 - pubs.rsc.org
Cell-penetrating peptides (CPPs) have found numerous applications in biology and
medicine since the first synthetic cell-permeable sequence was identified two decades ago …

Cell penetrating peptides: efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules

SM Farkhani, A Valizadeh, H Karami, S Mohammadi… - Peptides, 2014 - Elsevier
Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult
challenge. The cellular membrane is very effective in its role as a selectively permeable …

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

SH Nam, J Park, H Koo - Archives of Pharmacal Research, 2023 - Springer
Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …

Cell-penetrating peptides: strategies for anticancer treatment

D Raucher, JS Ryu - Trends in molecular medicine, 2015 - cell.com
Cell-penetrating peptides (CPP) provide an efficient strategy for the intracellular delivery of
bioactive molecules in various biomedical applications. This review focuses on recent …

Mechanism matters: a taxonomy of cell penetrating peptides

WB Kauffman, T Fuselier, J He, WC Wimley - Trends in biochemical …, 2015 - cell.com
The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …

Applications and challenges for use of cell-penetrating peptides as delivery vectors for peptide and protein cargos

M Kristensen, D Birch, H Mørck Nielsen - International journal of …, 2016 - mdpi.com
The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …

Intracellular delivery of molecular cargo using cell-penetrating peptides and the combination strategies

H Li, TY Tsui, W Ma - International journal of molecular sciences, 2015 - mdpi.com
Cell-penetrating peptides (CPPs) can cross cellular membranes in a non-toxic fashion,
improving the intracellular delivery of various molecular cargos such as nanoparticles, small …

Cell penetration: scope and limitations by the application of cell‐penetrating peptides

S Reissmann - Journal of Peptide Science, 2014 - Wiley Online Library
The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Recent advances in cell penetrating peptide-based anticancer therapies

J Habault, JL Poyet - Molecules, 2019 - mdpi.com
Cell-penetrating-peptides (CPPs) are small amino-acid sequences characterized by their
ability to cross cellular membranes. They can transport various bioactive cargos inside cells …