Local anesthetics are drugs that produce reversible loss of sensation in an area of an
animal's body without the loss of consciousness or alteration of central nervous system …

Local anesthetics are the only class of drugs that can fully block nociceptive impulses from
reaching the cerebral cortex and, thus, they represent the only means of completely …

Local anesthetics reversibly block the generation and propagation of electrical impulses in
nerves, thereby causing sensory and motor blockade. They are primarily used for local and …

This article discusses the physiology of normal nerve conduction, pain, and local anesthetic
mechanism of action. The pharmacology of local anesthetics with regard to uptake …

This chapter presents the mechanism of action, physicochemical properties,
pharmacokinetics of local anesthetics, and discusses the local anesthetic adjuvants and …

Until recently, local and regional anesthetic techniques had not gained widespread
acceptance in small animal practice. Lack of instruction at North American veterinary …

The physiochemical properties of common local anesthetic agents are discussed. Advances
in spinal opioid and spinal α 2-adrenergic administration have had a large impact on pain …

The fit local anaesthetic (LA) was cocaine. derived from the leaves of the Erythroxylon coca
shrub in the Andes Mountains. The drug was fist isolated in 1860. When touched to the …

Local anesthesia is indicated as part of a multimodal approach to anesthesia by treating and
preventing acute and chronic pain caused by surgery and disease, and also by helping to …

Local anesthetics reversibly block the generation and propagation of electrical impulses in
nerves, thereby causing sensory and motor blockade. Local anesthetics are considered …