Apolipoprotein-4 allele (APOE-4) as a Mediator of Cognitive Loss and Dementia in Long COVID-19

K Maiese - Current Neurovascular Research, 2022 - ingentaconnect.com
The sporadic form of Alzheimer's disease (AD) represents most of the clinical cases for AD
and at least ten percent of the global population over the age of 65 are affected by sporadic …

APOE4: a culprit for the vulnerability of COVID-19 in Alzheimer's patients

A Goyal, PS Kushwah, N Agrawal… - Current Neurovascular …, 2023 - ingentaconnect.com
Apolipoprotein E4 (APOE4) is one of the primary genetic risk factors for late-onset of
Alzheimer's disease (AD). While its primary function is to transport cholesterol, it also …

Relation between apolipoprotein e in alzheimer's disease and Sars-CoV-2 and their treatment strategy: A review

AK Ramachandran, S Das, GG Shenoy… - CNS & Neurological …, 2024 - ingentaconnect.com
COVID-19, which primarily affects the pulmonary system, turned out to be a global
pandemic, whereas the effects on other systems are still unknown. SARS-CoV-2, binds to …

Post-COVID-19 cognitive decline and apoe polymorphism: towards a possible link?

JWL Tavares-Júnior, DN Oliveira, JBS da Silva… - Brain Sciences, 2023 - mdpi.com
APOE ε4 polymorphism has been recently described as a possible association with
cognitive deficits in COVID-19 patients. This research aimed to establish the correlation …

APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical …

SN Kurki, J Kantonen, K Kaivola, L Hokkanen… - Acta neuropathologica …, 2021 - Springer
Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased
susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic …

Severe COVID-19 in Alzheimer's disease: APOE4's fault again?

N Xiong, MR Schiller, J Li, X Chen, Z Lin - Alzheimer's research & therapy, 2021 - Springer
Challenges have been recognized in healthcare of patients with Alzheimer's disease (AD) in
the COVID-19 pandemic, given a high infection and mortality rate of COVID-19 in these …

Cognitive impact of COVID-19: looking beyond the short term

S Miners, PG Kehoe, S Love - Alzheimer's research & therapy, 2020 - Springer
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

Links between COVID-19 and Alzheimer's disease—what do we already know?

E Rudnicka-Drożak, P Drożak, G Mizerski… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a life-changing condition whose etiology is explained by several
hypotheses. Recently, a new virus contributed to the evidence of viral involvement in AD: the …

The COVID-19 pandemic and Alzheimer's disease: mutual risks and mechanisms

F Chen, Y Chen, Y Wang, Q Ke, L Cui - Translational neurodegeneration, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

Y Zhou, J Xu, Y Hou, JB Leverenz, A Kallianpur… - Alzheimer's research & …, 2021 - Springer
Background Dementia-like cognitive impairment is an increasingly reported complication of
SARS-CoV-2 infection. However, the underlying mechanisms responsible for this …