The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several
complementary effects on cellular function that are favourable to healthspan; it is often …

SIRT1 is the closest mammalian homologue of enzymes that extend life in lower organisms.
Its role in mammals is incompletely understood, but includes modulation of at least 34 …

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-
dependent deacetylase that removes acetyl groups from various proteins. A wide variety of …

Abstract Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …

SIRT1 is a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase, which
removes acetyl groups from many target proteins, such as histone proteins, transcription …

Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2p, is a highly conserved NAD+-
dependent protein deacetylase that has emerged as a key cardiometabolic regulator. During …

Calorie restriction is considered to be the best environmental intervention providing health
benefits to mammals. The underlying mechanism of this intervention seems to be controlled …

Abstract The sirtuin 1 protein (SIRT1) is a member of the class III NAD+-dependent histone
deacetylases, which are also referred to as the 'sirtuins'. The sirtuins and silent information …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Background: Sirtuin 1–7 (SIRT1–7) are deacetylases that are dependent on NAD+ for their
activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and …