Several studies have shown that recipient-derived CD4+ CD25+ Foxp3+ regulatory T cells
(Tregs) are involved in transplantation tolerance. However, it is not clear whether allogeneic …

Regulatory T cells (Tregs), in particular CD4+ Foxp3+ T cells, have been shown to play an
important role in the maintenance of tolerance after allogeneic stem cell transplantation. In …

CD4+ regulatory T cells play a critical role in tolerance induction in transplantation. CD8+
suppressor T cells have also been shown to control alloimmune responses in preclinical …

The mechanisms by which CD4+ CD25+ Foxp3+ T (Treg) cells regulate effector T cells in a
transplantation setting and their in vivo homeostasis still remain to be clarified. Using a …

Current clinical strategies to control the alloimmune response after transplantation do not
fully prevent induction of the immunological processes which lead to acute and chronic …

Foxp3+ regulatory T cells (Tregs) have an essential role in immune and allograft tolerance.
However, in both kidney and liver transplantation in humans, FOXP3+ Tregs have been …

Abstract Naturally occurring FOXP3+ CD4+ Treg have a crucial role in self‐tolerance. The
ability to generate similar populations against alloantigens offers the possibility of preventing …

Background. FoxP3+/CD4+/CD25+ regulatory T cells (T reg) play an important role in
maintaining peripheral tolerance and are potent suppressors of T-cell activation. In this …

Background. Regulatory T (Treg) cells, generated in vitro by Foxp3 gene transfer into naive
CD4+ 25− T cells, have been shown to inhibit the development of inflammation and …

Adoptive transfer of polyclonal CD4+ CD25+ regulatory T cells (Treg) can tolerize
transplantation alloresponses. Treg are activated via their specific TCR, but the antigen …