Recent advances in the development and function of type II spiral ganglion neurons in the mammalian inner ear
In hearing, mechanically sensitive hair cells (HCs) in the cochlea release glutamate onto
spiral ganglion neurons (SGNs) to relay auditory information to the central nervous system …
spiral ganglion neurons (SGNs) to relay auditory information to the central nervous system …
Outer hair cell glutamate signaling through type II spiral ganglion afferents activates neurons in the cochlear nucleus in response to nondamaging sounds
CJC Weisz, SPG Williams, CS Eckard… - Journal of …, 2021 - Soc Neuroscience
Cochlear outer hair cells (OHCs) are known to uniquely participate in auditory processing
through their electromotility, and like inner hair cells, are also capable of releasing vesicular …
through their electromotility, and like inner hair cells, are also capable of releasing vesicular …
[HTML][HTML] Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system
Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …
[HTML][HTML] Sensory neuron diversity in the inner ear is shaped by activity
BR Shrestha, C Chia, L Wu, SG Kujawa, MC Liberman… - Cell, 2018 - cell.com
In the auditory system, type I spiral ganglion neurons (SGNs) convey complex acoustic
information from inner hair cells (IHCs) to the brainstem. Although SGNs exhibit variation in …
information from inner hair cells (IHCs) to the brainstem. Although SGNs exhibit variation in …
Molecular signatures define subtypes of auditory afferents with distinct peripheral projection patterns and physiological properties
C Siebald, PFY Vincent, RT Bottom… - Proceedings of the …, 2023 - National Acad Sciences
Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound
information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of …
information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of …
[HTML][HTML] The afferent signaling complex: regulation of type I spiral ganglion neuron responses in the auditory periphery
DOJ Reijntjes, SJ Pyott - Hearing Research, 2016 - Elsevier
The spiral ganglion neurons (SGNs) are the first action potential generating neurons in the
auditory pathway. The type I SGNs contact the sensory inner hair cells via their peripheral …
auditory pathway. The type I SGNs contact the sensory inner hair cells via their peripheral …
Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells
TM Coate, MW Kelley - Seminars in cell & developmental biology, 2013 - Elsevier
In mammals, auditory information is processed by the hair cells (HCs) located in the cochlea
and then rapidly transmitted to the CNS via a specialized cluster of bipolar afferent …
and then rapidly transmitted to the CNS via a specialized cluster of bipolar afferent …
[HTML][HTML] Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a Lmx1a Population in the Cochlea
FC Grandi, L De Tomasi, M Mustapha - Frontiers in molecular …, 2020 - frontiersin.org
In the mature cochlea, each inner hair cell (IHC) is innervated by multiple spiral ganglion
neurons of type I (SGNI). SGNIs are morphologically and electro-physiologically diverse …
neurons of type I (SGNI). SGNIs are morphologically and electro-physiologically diverse …
The ribbon synapse between type I spiral ganglion neurons and inner hair cells
MA Rutherford, T Moser - The primary auditory neurons of the mammalian …, 2016 - Springer
This chapter provides an overview of the first auditory synapses, in the cochlea where sound
is encoded. We review insights into the development, structure, and function of the excitatory …
is encoded. We review insights into the development, structure, and function of the excitatory …
Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice
Hearing over a wide range of sound intensities is thought to require complementary coding
by functionally diverse spiral ganglion neurons (SGNs), each changing activity only over a …
by functionally diverse spiral ganglion neurons (SGNs), each changing activity only over a …