[HTML][HTML] SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …
Discovery and genomic characterization of a 382-nucleotide deletion in ORF7b and ORF8 during the early evolution of SARS-CoV-2
To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …
Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene
F Pereira - Infection, Genetics and Evolution, 2020 - Elsevier
The new SARS-CoV-2 poses a significant threat to human health but many aspects of its
basic biology remain unknown. Its genome encodes accessory genes that differ significantly …
basic biology remain unknown. Its genome encodes accessory genes that differ significantly …
[PDF][PDF] SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
Summary Over 950,000 whole-genome sequences of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the …
coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the …
SARS-CoV-2 restructures host chromatin architecture
Some viruses restructure host chromatin, influencing gene expression, with implications for
disease outcome. Whether this occurs for SARS-CoV-2, the virus causing COVID-19, is …
disease outcome. Whether this occurs for SARS-CoV-2, the virus causing COVID-19, is …
[PDF][PDF] Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles
The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019
(COVID-19), a global healthcare and economic catastrophe. Understanding of the host …
(COVID-19), a global healthcare and economic catastrophe. Understanding of the host …
SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring
F Pereira - Biochemical and biophysical research communications, 2021 - Elsevier
Abstract The SARS-CoV-2 Variant of Concern 202012/01 (VOC-202012/01) emerged in
southeast England and rapidly spread worldwide. This variant is believed to be more …
southeast England and rapidly spread worldwide. This variant is believed to be more …
[HTML][HTML] The coding capacity of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …
SARS-CoV-2 ORF9c is a membrane-associated protein that suppresses antiviral responses in cells
Disrupted antiviral immune responses are associated with severe COVID-19, the disease
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …
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