[HTML][HTML] SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

J Kee, S Thudium, DM Renner, K Glastad, K Palozola… - Nature, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …

Discovery and genomic characterization of a 382-nucleotide deletion in ORF7b and ORF8 during the early evolution of SARS-CoV-2

YCF Su, DE Anderson, BE Young, M Linster, F Zhu… - MBio, 2020 - Am Soc Microbiol
To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …

Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene

F Pereira - Infection, Genetics and Evolution, 2020 - Elsevier
The new SARS-CoV-2 poses a significant threat to human health but many aspects of its
basic biology remain unknown. Its genome encodes accessory genes that differ significantly …

[PDF][PDF] SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression

A Nemudryi, A Nemudraia, T Wiegand, J Nichols… - Cell Reports, 2021 - cell.com
Summary Over 950,000 whole-genome sequences of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the …

SARS-CoV-2 restructures host chromatin architecture

R Wang, JH Lee, J Kim, F Xiong, LA Hasani, Y Shi… - Nature …, 2023 - nature.com
Some viruses restructure host chromatin, influencing gene expression, with implications for
disease outcome. Whether this occurs for SARS-CoV-2, the virus causing COVID-19, is …

[PDF][PDF] Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

T Kehrer, A Cupic, C Ye, S Yildiz, M Bouhaddou… - Cell Host & Microbe, 2023 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

AM Gamage, KS Tan, WOY Chan, J Liu, CW Tan… - PLoS …, 2020 - journals.plos.org
The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019
(COVID-19), a global healthcare and economic catastrophe. Understanding of the host …

SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring

F Pereira - Biochemical and biophysical research communications, 2021 - Elsevier
Abstract The SARS-CoV-2 Variant of Concern 202012/01 (VOC-202012/01) emerged in
southeast England and rapidly spread worldwide. This variant is believed to be more …

[HTML][HTML] The coding capacity of SARS-CoV-2

Y Finkel, O Mizrahi, A Nachshon… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …

SARS-CoV-2 ORF9c is a membrane-associated protein that suppresses antiviral responses in cells

A Dominguez Andres, Y Feng, AR Campos, J Yin… - BioRxiv, 2020 - biorxiv.org
Disrupted antiviral immune responses are associated with severe COVID-19, the disease
caused by SAR-CoV-2. Here, we show that the 73-amino-acid protein encoded by ORF9c of …