Glial cells are directly or indirectly affected by estradiol and by different estrogenic
compounds, such as selective estrogen receptor modulators. Acting on oligodendrocytes …

Gonadal steroids are known to be of prime importance in the normal maintenance of brain
function. Data from epidemiological studies suggest that the decline in estrogen following …

This review highlights recent evidence from clinical and basic science studies supporting a
role for estrogen in neuroprotection. Accumulated clinical evidence suggests that estrogen …

Background Recent work has suggested that the ovarian steroid 17β-estradiol, at
physiological concentrations, may exert protective effects in neurodegenerative disorders …

Traumatic brain injury (TBI) is a serious public health problem. It may result in severe
neurological disabilities and in a variety of cellular metabolic alterations for which available …

Epidemiological studies associate post-menopausal estrogen use with a reduction in risk of
Alzheimer's disease, a reduction in risk of Parkinson's disease, and death from stroke. The …

Over the past decade our recognition that estrogens function as important neurotrophic and
neuroprotective factors has grown rapidly. Accumulating evidence from basic science …

The role of estrogen during brain development is well documented. Estrogen influences cell
survival and differentiation and also controls the formation and maintenance of neural …

Neuroprotective actions of 17β-estradiol (estradiol) are in part mediated by direct actions on
neurons. Astrocytes, which play an essential role in the maintenance of the homeostasis of …

For many molecules, which have been found first in a certain tissue and with a certain
activity in the body, multiple activities have been discovered decades later. The steroidal …