Vulnerable atherosclerotic plaque rupture is the principal mechanism that accounts for
myocardial infarction and stroke. High matrix metalloproteinase-9 (MMP-9) expression and …

Matrix metalloproteinase‐9 (MMP‐9) belongs to the MMP family and has been widely
investigated. Excessive MMP‐9 expression can enhance extracellular matrix degradation …

Atherosclerotic plaques are composed of a lipid rich core, which is covered by a collagen
rich fibrous cap. Rupture of the atherosclerotic plaque with superimposed thrombosis is the …

Background and aims Matrix metalloproteinases (MMPs) have been implicated in
atherosclerosis and vascular calcification. Among them, we reported that MMP10 is present …

Background Transforming growth factor beta (TGF-β) and matrix metalloproteinases-9 (MMP-
9) have been implicated in the pathogenesis of human atherosclerosis but their relationship …

Background—Matrix metalloproteinase-9 (MMP-9) is involved in atherosclerosis and
elevated MMP-9 activity has been found in unstable plaques, suggesting a crucial role in …

The prevalence of atherosclerotic disease continues to increase, and despite significant
reductions in major cardiovascular events with current medical interventions, an additional …

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have
been shown to reduce cardiovascular morbidity and mortality by their actions on atherogenic …

Objective—Evidence has linked collagen loss with the onset of acute coronary events. This
study tested the hypothesis that selective matrix metalloproteinase-13 (MMP-13) …

Matrix metalloproteinases degrade the collagen content of atherosclerotic plaque and
reduce plaque stability. In tissue sections of atherosclerotic plaque, the expression of matrix …