Background: Recent findings have shown a correlation between the intrathecal IgG index
and variants at the immunoglobulin heavy chain (IGHC) locus in patients with multiple …

Objective: Intrathecal synthesis of immunoglobulin gamma (IgG) synthesis is frequently
observed in patients with multiple sclerosis (MS). Whereas the extent of intrathecal IgG …

Clonally related B cells infiltrate the brain, meninges, and cerebrospinal fluid of MS patients,
but the mechanisms driving the B‐cell response and shaping the immunoglobulin …

Objective In this observational study, we investigated the impact of genetic factors at the
immunoglobulin heavy chain constant locus on chromosome 14 and the major …

The restricted use of immunoglobulin heavy chain variable (IGHV) family 4 gene segments
by clonally expanded B cells in brain lesions and cerebrospinal fluid (CSF) of multiple …

Immunological hallmarks of multiple sclerosis include the production of antibodies in the
central nervous system, expressed as presence of oligoclonal bands and/or an increased …

Increased intrathecal IgG and oligoclonal bands (OCB) are seminal features of multiple
sclerosis (MS). Although no such differences in MS blood total IgG antibodies have been …

IgG, its subclasses and IgE concentrations were measured in cerebrospinal fluid (CSF) and
serum of multiple sclerosis (MS) patients and matched controls as surrogate markers for type …

Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous
system. Autoantibodies are thought to participate in the pathogenesis. Previous reports on …

In addition to the major histocompatibility complex (MHC), genetic susceptibility in multiple
sclerosis (MS) appears to be influenced by other loci. A recent study has identified a …