Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

Obstructive sleep apnea: current perspectives

AM Osman, SG Carter, JC Carberry… - Nature and science of …, 2018 - Taylor & Francis
The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

Pathophysiology of adult obstructive sleep apnea

DJ Eckert, A Malhotra - Proceedings of the American thoracic …, 2008 - atsjournals.org
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive narrowing
or collapse of the pharyngeal airway during sleep. The disorder is associated with major …

Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Obstructive sleep apnea

DP White, MK Younes - Comprehensive Physiology, 2012 - Wiley Online Library
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive collapse of
the pharyngeal airway during sleep. Control of pharyngeal patency is a complex process …

Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care

JL Pépin, P Eastwood, DJ Eckert - European Respiratory …, 2022 - Eur Respiratory Soc
Recent advances in obstructive sleep apnoea (OSA) pathophysiology and translational
research have opened new lines of investigation for OSA treatment and management. Key …

[HTML][HTML] The pathogenesis of obstructive sleep apnea

LV Pham, AR Schwartz - Journal of thoracic disease, 2015 - ncbi.nlm.nih.gov
Obstructive sleep apnea (OSA) is a major source of cardiovascular morbidity and mortality,
and represents an increasing burden on health care resources. Understanding underlying …

[HTML][HTML] From CPAP to tailored therapy for obstructive sleep apnoea

K Sutherland, K Kairaitis, BJ Yee, PA Cistulli - Multidisciplinary Respiratory …, 2018 - Springer
Abstract Obstructive Sleep Apnoea (OSA) is a common sleep disorder that is associated with
daytime symptoms and a range of comorbidity and mortality. Continuous Positive Airway …

Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature

RL Owens, DJ Eckert, SY Yeh… - Current opinion in …, 2008 - journals.lww.com
Ongoing studies are attempting to classify patients on the basis of the underlying
pathophysiology. This work suggests that obstructive sleep apnea is a heterogeneous …

Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets

DJ Eckert, DP White, AS Jordan, A Malhotra… - American journal of …, 2013 - atsjournals.org
Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …