Pharmacological therapies and factors delivery for spinal cord injury regeneration

SP Zustiak, S Sheth, M Imaninezhad - Spinal Cord Injury (SCI) Repair …, 2020 - Elsevier
Spinal cord injury (SCI) is one of the major causes of irreversible nerve injury, affecting both
sensory and motor neurons, which poses a significant physical, emotional, and economic …

A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury

N Hejrati, MG Fehlings - Current Opinion in Pharmacology, 2021 - Elsevier
Traumatic spinal cord injuries (SCIs) have far-reaching physical, social, and financial
consequences. While medical advancements have improved supportive therapeutic …

Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

S Kabu, Y Gao, BK Kwon, V Labhasetwar - Journal of Controlled Release, 2015 - Elsevier
Spinal cord injury (SCI) results in devastating neurological and pathological consequences,
causing major dysfunction to the motor, sensory, and autonomic systems. The primary …

Clinical and experimental advances in regeneration of spinal cord injury

JK Hyun, HW Kim - Journal of tissue engineering, 2010 - journals.sagepub.com
Spinal cord injury (SCI) is one of the major disabilities dealt with in clinical rehabilitation
settings and is multifactorial in that the patients suffer from motor and sensory impairments …

Recent advances in regenerative medicine approaches for spinal cord injuries

MH Hettiaratchi, T Führmann, MS Shoichet - Current Opinion in Biomedical …, 2017 - Elsevier
Traumatic injury to the spinal cord leads to a loss of motor and sensory function below the
level of injury. The lack of growth-associated proteins, local expression of inhibitory factors …

[HTML][HTML] Sustained delivery of neurotrophic factors to treat spinal cord injury

A Muheremu, L Shu, J Liang, A Aili… - Translational …, 2021 - degruyter.com
Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical
and psychological harm and a series of socioeconomic problems. Although neurons in the …

Translational perspective: neuroregenerative strategies and therapeutics for traumatic spinal cord injury

AJ Santamaria, PM Saraiva, JP Solano… - Neural Repair and …, 2022 - Elsevier
The last three decades have witnessed transformative advances in biology and
neuroscience. Still, regeneration of axons after traumatic spinal cord injury (SCI) remains a …

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

A Blesch, MH Tuszynski - Trends in neurosciences, 2009 - cell.com
Over the past three decades, multiple mechanisms limiting central nervous system
regeneration have been identified. Here, we address plasticity arising from spared systems …

Spinal cord clinical trials and the role for bioengineering

JT Wilcox, D Cadotte, MG Fehlings - Neuroscience letters, 2012 - Elsevier
There is considerable need for bringing effective therapies for spinal cord injury (SCI) to the
clinic. Excellent medical and surgical management has mitigated poor prognoses after SCI; …

Neuroprotection and regeneration strategies for spinal cord repair

EC Tsai, CH Tator - Current pharmaceutical design, 2005 - ingentaconnect.com
The journey toward a cure for spinal cord injury (SCI) has taken many paths. In this article,
we review these paths, and highlight the clinical applications of these experimental repair …