The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

Klotho is highly expressed in the kidney and a soluble form of Klotho functions as an
endocrine substance that exerts multiple actions including the modulation of renal solute …

Klotho is a single-pass transmembrane protein highly expressed in the kidney. Membrane
Klotho protein acts as a co-receptor for fibroblast growth factor-23. Its extracellular domain is …

Klotho in health and disease : Current Opinion in Nephrology and Hypertension Klotho in
health and disease : Current Opinion in Nephrology and Hypertension Log in or Register …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …

Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

Klotho is a single-pass transmembrane protein that exerts its biological functions through
multiple modes. Membrane-bound Klotho acts as coreceptor for the major phosphatonin …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the …