The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

Background Pain is generally concomitant with an inflammatory reaction at the site where
the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal …

Here, in this review, we present our hypothesis of the migraine pathogenesis. We believe
that migraine attacks derive from a top-down dysfunctional process that initiates in a …

Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Article abstract-The trigeminal nerve transmits headache pain from blood vessels of the pia
mater and dura mater. Triggers for this pain are not well understood, but probably are …

The pathogenesis of migraine is still unclear, but much evidence led us hypothesize that it
can be associated with immune system modification, so that a role for cytokines has been …

Neurogenic inflammation, a well-defined pathophysiologial process is characterized by the
release of potent vasoactive neuropeptides, predominantly calcitonin gene-related peptide …

Despite considerable research into the pathogenesis of idiopathic headaches, such as
migraine, the pathophysiological mechanisms underlying them remain poorly understood …

Experimental findings suggest an involvement of neuroinflammatory mechanisms in the
pathophysiology of migraine. Specifically, preclinical models of migraine have emphasized …