The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in
treatment of various human cancers. CK2 overexpression has been demonstrated in …

Relapsed and refractory lymphoid and myeloid malignancies are often characterized by
progressive resistance to standard chemotherapy as well as poor long-term outcomes …

Abstract Casein kinase 2 (CK2) is involved in multiple cellular processes such as
proliferation, apoptosis, and cell cycle. In particular, its over-expression in human cancers is …

Background: Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a
promising therapeutic target in cancer. Recent studies have revealed an important role for …

Abstract Background Casein kinase 2 (CK2) is dysregulated in various human cancers and
is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven
CK1 isoforms identified in humans. The most important substrates of CK1 kinases are …

Casein kinase 2 (CK2) is highly expressed in cancer and has been considered a potential
therapeutic target. Wells and colleagues developed and characterized the new CK2 inhibitor …

Background The involvement of protein kinase CK2 in sustaining cancer cell survival could
have implications also in the resistance to conventional and unconventional therapies …

CK2 is a protein kinase involved in several human diseases (ranging from neurological and
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …