Leptin resistance during aging is independent of fat mass

I Gabriely, XH Ma, XM Yang, L Rossetti, N Barzilai - Diabetes, 2002 - Am Diabetes Assoc
Increased fat mass, abdominal adiposity, and insulin resistance are typical findings in aging
mammals and are frequently associated with leptin resistance and increased plasma leptin …

Aging is associated with resistance to effects of leptin on fat distribution and insulin action

XH Ma, R Muzumdar, XM Yang… - The Journals of …, 2002 - academic.oup.com
Leptin has been shown to modulate total body fat and visceral fat distribution and to
enhance insulin action in young rats. We hypothesize that failure of leptin action may …

Role of leptin resistance in the development of obesity in older patients

S Carter, A Caron, D Richard… - Clinical interventions in …, 2013 - Taylor & Francis
Obesity is a global epidemic associated with aging-like cellular processes; in both aging and
obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a …

Peripheral and hypothalamic leptin resistance with age-related obesity

PJ Scarpace, N Tümer - Physiology & behavior, 2001 - Elsevier
Leptin contributes to the regulation of both food intake and energy expenditure. Serum leptin
is elevated in most obese humans, and that obesity persists in spite of the elevated leptin …

Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats

C Fernandez-Galaz, T Fernandez-Agullo, C Perez… - Diabetologia, 2002 - Springer
Heading Abstract Aims/hypothesis. Ageing is associated with insulin and leptin resistance in
mammals. These alterations might be caused by the increased adiposity associated with …

Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats

PJ Scarpace, M Matheny, N Tümer - Neuroscience, 2001 - Elsevier
Leptin contributes to the regulation of both food intake and energy expenditure. We
previously demonstrated that the F344× BN rat, a rodent model for late-onset obesity, is …

Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age

J Qiu, S Ogus, R Lu, FF Chehab - Endocrinology, 2001 - academic.oup.com
Sensitivity to leptin is associated with a normal regulation of the adipose mass, whereas
decreased leptin sensitivity results in elevated adipose tissue stores. To address whether …

The role of leptin resistance in the lipid abnormalities of aging

ZWEI WANG, WENT PAN, Y Lee, T Kakuma… - The FASEB …, 2001 - Wiley Online Library
Leptin resistance has been implicated in the pathogenesis of obesity‐related complications
involving abnormalities of lipid metabolism that resemble those of old age. To determine …

Effects of nutritional status and aging on leptin gene expression in mice: importance of glucose

T Mizuno, H Bergen, S Kleopoulos… - Hormone and …, 1996 - thieme-connect.com
The factors regulating leptin mRNA under physiological conditions have not been fully
elucidated, although both insulin and glucose have been implicated. Since, in male mice …

Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance

M Balaskó, S Soós, M Székely, E Pétervári - Journal of chemical …, 2014 - Elsevier
Leptin is produced mainly in the white adipose tissue and emerged as one of the key
catabolic regulators of food intake and energy expenditure. During the course of aging …