Prior evidence indicates that the infralimbic cortex (IL) mediates the ongoing inhibition of
cocaine seeking following self-administration and extinction training in rats, specifically …

The infralimbic cortex (IL) mediates extinction learning and the active suppression of
cocaine-seeking behavior. However, the precise temporal relationship among IL activity …

The infralimbic cortex (IL) regulates the consolidation of extinction learning for fear
conditioning. Whether the IL influences the consolidation of extinction learning for cocaine …

The rat prelimbic prefrontal cortex and nucleus accumbens core are critical for initiating
cocaine seeking. In contrast, the neural circuitry responsible for inhibiting cocaine seeking …

Animal models of relapse reveal that the motivation to seek drug is regulated by enduring
morphological and physiological changes in the nucleus accumbens, as well as transient …

Memory system circuitry may regulate how cues associated with cocaine are extinguished,
and understanding neurosubstrates of extinction may lead to the development of improved …

Sites within the hippocampus, amygdala and prefrontal cortex may regulate how responses
maintained by cues associated with cocaine are extinguished. To test the role of various …

Stimuli previously associated with drugs of abuse can become triggers that elicit craving and
lead to drug-seeking behavior. The basolateral amygdala (BLA) is a key neural structure …

Evidence indicates that the anterior (aIC), but not posterior (pIC), insular cortex promotes
cued reinstatement of cocaine seeking after extinction in rats. It is unknown whether these …

One strategy proposed to treat addictive disorders is to extinguish the association between
environmental stimuli (cues) and actions associated with drug use to reduce relapse. The …