Background Macrolides are a class of broad-spectrum antibiotics of large molecular size.
The class includes erythromycin, clarithromycin, and azithromycin, among others 1 …

The macrolide antimicrobial family is a comprised of 14, 15 and 16 member-ringed
compounds that are characterized by similar chemical structures, mechanisms of action and …

The pharmacokinetic aspects in humans of macrolide antibiotics that are currently or soon to
be on the market (ie erythromycin, oleandomycin, spiramycin, josamycin, midecamycin …

Erythromycin and related macrolide antibiotics have recently enjoyed a resurgence of
clinical interest. This is a result of activity against organisms which are becoming more …

Two of the most significant changes in the field of infectious disease management during the
last few decades are the emergence of atypical and/or new pathogens that may have …

Three pharmacokinetic/pharmacodynamic parameters—(i) the peak concentration to the
minimum inhibitory concentration ratio (Cmax/MIC);(ii) the area under the concentration …

Erythromycin, which was introduced over 50 years ago, was the first macrolide to be used
clinically." New" macrolides, for the treatment of patients with various infectious diseases …

Macrolide antibiotics can interact adversely with commonly used drugs, usually by altering
metabolism due to complex formation and inhibition of cytochrome P-450 IIIA4 (CYP3A4) in …

The macrolides are generally well tolerated when used for the treatment of acute infections.
Even when given long term for prophylaxis, there are few discontinuations due to side …

OBJECTIVE: To review the chemistry, antimicrobial spectrum, pharmacokinetics, clinical
trials, adverse effects, and drug interactions of four new macrolide antibiotics: Azithromycin …