Genetic variation has a significant impact on an individual's metabolism and response to a
wide range of medications. The cytochrome P450 family of enzymes are key determinants in …

The CYP2D6 gene encodes an enzyme important in the metabolism of many commonly
used medications. Variation in CYP2D6 is associated with inter-individual differences in …

CYP2D6 is of great importance for the metabolism of clinically used drugs and about 20–
25% of those are metabolised by this enzyme. In addition, the enzyme utilises …

Purpose: Owing to its highly polymorphic nature and major contribution to the metabolism
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …

The cytochrome P450 2D6 (CYP2D6) enzyme contributes to the metabolism and/or
bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is …

Cytochromes P450 are members of a superfamily of hemoproteins that catalyze a variety of
oxidative reactions in the metabolism of endogenous and exogenous hydrophobic …

Methods This article reviews the information derived from various studies over the past
decade and explains the molecular basis of functional differences in CYP2D6 variants …

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in
the 1970s. This is because of its involvement in the metabolism of more than 25% of the …

We analyzed CYP2D6 in two individuals characterized by impaired sparteine oxidation
(intermediate metabolizer phenotype) and genotype 2D6* 2/* 4 (1661G> C; 2850C> T; …

Methods A total of 1060 individuals belonging to 52 worldwide-distributed populations were
genotyped at 12 highly informative variable sites, as well as for gene deletion and …