[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …
[HTML][HTML] Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study
Epigenome-wide studies of methylation in children support a role for epigenetic
mechanisms in asthma; however, studies in adults are rare and few have examined non …
mechanisms in asthma; however, studies in adults are rare and few have examined non …
Nasal DNA methylation profiling of asthma and rhinitis
Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights …
the environment and an accessible proxy for the bronchial epithelium, might provide insights …
[HTML][HTML] Epigenome-wide association study of asthma and wheeze in childhood and adolescence
Background Asthma heritability has only been partially explained by genetic variants and is
known to be sensitive to environmental factors, implicating epigenetic modifications such as …
known to be sensitive to environmental factors, implicating epigenetic modifications such as …
The nasal methylome and childhood atopic asthma
IV Yang, BS Pedersen, AH Liu, GT O'Connor… - Journal of Allergy and …, 2017 - Elsevier
Background Given the strong environmental influence on both epigenetic marks and allergic
asthma in children, the epigenetic alterations in respiratory epithelia might provide insight …
asthma in children, the epigenetic alterations in respiratory epithelia might provide insight …
DNA methylation and childhood asthma in the inner city
IV Yang, BS Pedersen, A Liu, GT O'Connor… - Journal of Allergy and …, 2015 - Elsevier
Background Epigenetic marks are heritable, influenced by the environment, direct the
maturation of T lymphocytes, and in mice enhance the development of allergic airway …
maturation of T lymphocytes, and in mice enhance the development of allergic airway …
The role of epigenetics in the development of childhood asthma
Introduction: The development of childhood asthma is caused by a combination of genetic
factors and environmental exposures. Epigenetics describes mechanisms of (heritable) …
factors and environmental exposures. Epigenetics describes mechanisms of (heritable) …
Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy
LP Gunawardhana, KJ Baines, J Mattes… - Pediatric …, 2014 - Wiley Online Library
Background Asthma is a complex disease that involves both genetic factors and
environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may …
environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may …