[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma

SE Reese, CJ Xu, HT Den Dekker, MK Lee… - Journal of Allergy and …, 2019 - Elsevier
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

E Forno, T Wang, C Qi, Q Yan, CJ Xu… - The lancet Respiratory …, 2019 - thelancet.com
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

[HTML][HTML] Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study

TT Hoang, S Sikdar, CJ Xu, MK Lee… - European …, 2020 - Eur Respiratory Soc
Epigenome-wide studies of methylation in children support a role for epigenetic
mechanisms in asthma; however, studies in adults are rare and few have examined non …

Nasal DNA methylation profiling of asthma and rhinitis

C Qi, Y Jiang, IV Yang, E Forno, T Wang… - Journal of allergy and …, 2020 - Elsevier
Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights …

[HTML][HTML] Epigenome-wide association study of asthma and wheeze in childhood and adolescence

R Arathimos, M Suderman, GC Sharp, K Burrows… - Clinical …, 2017 - Springer
Background Asthma heritability has only been partially explained by genetic variants and is
known to be sensitive to environmental factors, implicating epigenetic modifications such as …

The nasal methylome and childhood atopic asthma

IV Yang, BS Pedersen, AH Liu, GT O'Connor… - Journal of Allergy and …, 2017 - Elsevier
Background Given the strong environmental influence on both epigenetic marks and allergic
asthma in children, the epigenetic alterations in respiratory epithelia might provide insight …

DNA methylation and childhood asthma in the inner city

IV Yang, BS Pedersen, A Liu, GT O'Connor… - Journal of Allergy and …, 2015 - Elsevier
Background Epigenetic marks are heritable, influenced by the environment, direct the
maturation of T lymphocytes, and in mice enhance the development of allergic airway …

The role of epigenetics in the development of childhood asthma

C Qi, CJ Xu, GH Koppelman - Expert review of clinical immunology, 2019 - Taylor & Francis
Introduction: The development of childhood asthma is caused by a combination of genetic
factors and environmental exposures. Epigenetics describes mechanisms of (heritable) …

Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy

LP Gunawardhana, KJ Baines, J Mattes… - Pediatric …, 2014 - Wiley Online Library
Background Asthma is a complex disease that involves both genetic factors and
environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may …