Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and
cellular conditions. The mechanistic details of how a cell chooses among these cell fates are …

The extrinsic apoptotic pathway is initiated by death receptor activation. Death receptor
activation leads to the formation of death receptor signaling platforms, resulting in the …

Apoptosis is a highly regulated cell death mechanism involved in many physiological
processes. A key component of extrinsically activated apoptosis is the death receptor Fas …

Background Apoptosis is a form of programmed cell death essential for the maintenance of
homeostasis and the removal of potentially damaged cells in multicellular organisms. By …

Apoptosis is an important physiological process crucially involved in development and
homeostasis of multicellular organisms. Although the major signaling pathways have been …

When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand
(TRAIL), a closely related death ligand and investigational therapeutic, cells enter a …

Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the
elimination of cells via a complex but highly defined cellular programme. Defects in the …

Mathematical modeling is required for understanding the complex behavior of large signal
transduction networks. Previous attempts to model signal transduction pathways were often …

The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis
induction by various stimuli including cytotoxic stress. It depends on the cellular context …

Apoptosis is a form of programmed cell death, which is fundamental to all multicellular
organisms. Deregulation of apoptosis leads to a number of severe diseases including …