Chromatin accessibility plays an essential role in controlling cellular identity and the
therapeutic response of human cancers. However, the chromatin accessibility landscape …

Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma
(PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular …

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated …

INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Adaptive drug-resistance mechanisms allow human tumors to evade treatment through
selection and expansion of treatment-resistant clones. Here, studying clonal evolution of …

Epigenetic mechanisms contribute to the initiation and development of cancer, and
epigenetic variation promotes dynamic gene expression patterns that facilitate tumor …

Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of
novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank …

Systematic studies of cancer genomes have provided unprecedented insights into the
molecular nature of cancer. Using this information to guide the development and application …

Chromatin accessibility is essential in regulating gene expression and cellular identity, and
alterations in accessibility have been implicated in driving cancer initiation, progression and …

Background Pancreatic cancer's poor prognosis is caused by distal metastasis, which is
associated with epigenetic changes. However, the role of the 3D epigenome in pancreatic …