Relapse of prostate cancer after androgen ablation therapy is hormone-refractory, with
continued tumor growth being dependent on the androgen receptor (AR). E2F-1, a regulator …

Thymoquinone (TQ), an active ingredient of black seed oil (Nigella Sativa), has been shown
to possess antineoplastic activity against a variety of experimental tumors. However, the …

Background The treatment of castrate-resistant prostate cancer (CRPC) still remains as an
important challenge of daily oncology practice. Docetaxel significantly prolongs overall …

Thymoquinone, a component derived from the medial plant Nigella sativa, has been used
for medical purposes for more than 2,000 years. Recent studies reported that thymoquinone …

Hinokitiol (β-thujaplicin), a troplone-related compound found in the heartwood of
cupressaceous plants, strongly inhibits the proliferation of a broad range of tumor cell lines …

The androgen receptor (AR) is involved in the development and progression of prostate
cancer. In order to find new compounds that may present novel mechanisms to attenuate the …

Despite recent advances in understanding the biological basis of prostate cancer,
management of the disease, especially in the phase resistant to androgen ablation, remains …

Promotion of apoptosis in cancer cells could potentially lead to the regression and improved
prognosis of hormone-refractory prostate cancer. Xanthohumol (XN), a prenylated chalcone …

Forkhead box O (FoxO) transcription factors play an important role as tumor suppressor in
several human malignancies. Disruption of FoxO activity due to loss of phosphatase and …

Purpose: Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines
in Taiwan and southern China. Inflammation is involved in promoting tumor growth …