Mitochondrial mechanisms of neuroglobin's neuroprotection

Z Yu, JL Poppe, X Wang - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Neuroglobin (Ngb) is an oxygen‐binding globin protein that has been demonstrated to be
neuroprotective against stroke and related neurological disorders. However, the underlying …

Neuroglobin and mitochondria: The impact on neurodegenerative diseases

M Fiocchetti, P Cracco, E Montalesi… - Archives of Biochemistry …, 2021 - Elsevier
Dysfunctional mitochondria have severe consequences on cell functions including Reactive
Oxygen Specie (ROS) generation, alteration of mitochondrial signaling, Ca 2+ buffering, and …

[HTML][HTML] The potential of mitochondrial modulation by neuroglobin in treatment of neurological disorders

AM Gorabi, S Aslani, GE Barreto, E Baez-Jurado… - Free Radical Biology …, 2021 - Elsevier
Neuroglobin is the third member of the globin family to be identified in 2000 in neurons of
both human and mouse nervous systems. Neuroglobin is an oxygen-binding globin found in …

Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons

Z Yu, Y Zhang, N Liu, J Yuan, L Lin, Q Zhuge… - Molecular …, 2016 - Springer
Neuroglobin (Ngb) is a tissue globin specifically expressed in brain neurons. Recent studies
by our laboratory and others have demonstrated that Ngb is protective against stroke and …

Mitochondrial distribution of neuroglobin and its response to oxygen–glucose deprivation in primary-cultured mouse cortical neurons

Z Yu, J Xu, N Liu, Y Wang, X Li, S Pallast, K van Leyen… - Neuroscience, 2012 - Elsevier
Neuroglobin (Ngb) is a new member of the globin family and a novel endogenous
neuroprotective molecule, but its neuroprotective mechanisms remain largely undefined …

Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons

J Liu, Z Yu, S Guo, SR Lee, C Xing… - Journal of …, 2009 - Wiley Online Library
Neuroglobin (Ngb) is a recently discovered tissue globin with a high affinity for oxygen that is
widely and specifically expressed in neurons of vertebrate central and peripheral nervous …

Identification of neuroglobin-interacting proteins using yeast two-hybrid screening

Z Yu, N Liu, Y Wang, X Li, X Wang - Neuroscience, 2012 - Elsevier
Neuroglobin (Ngb) is a globin protein that is highly and specifically expressed in brain
neurons. A large volume of evidence has proven that Ngb is a neuroprotective molecule …

Neuroprotective roles and mechanisms of neuroglobin

Z Yu, X Fan, EH Lo, X Wang - Neurological research, 2009 - Taylor & Francis
Objective: The objectives of this work were to update and summarize recent experimental
works on neuroglobin, mainly focus on its neuroprotective effects and the mechanisms …

Neuroglobin: From structure to function in health and disease

P Ascenzi, A di Masi, L Leboffe, M Fiocchetti… - Molecular aspects of …, 2016 - Elsevier
In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders

Z Yu, N Liu, J Liu, K Yang, X Wang - International journal of molecular …, 2012 - mdpi.com
Brain neurons and tissues respond to sublethal injury by activating endogenous protective
pathways. Recently, following the failure of a large number of clinical trials for protective …