Structure-based derivation and intramolecular cyclization of peptide inhibitors from PD-1/PD-L1 complex interface as immune checkpoint blockade for breast cancer …
K Zhou, J Lu, X Yin, H Xu, L Li, B Ma - Biophysical chemistry, 2019 - Elsevier
The interaction event between programmed death receptor-1 (PD-1) and its ligand (PD-L1)
functions as an essential immune checkpoint against cytotoxic T effector cell activation …
functions as an essential immune checkpoint against cytotoxic T effector cell activation …
Discovery of cyclic peptide inhibitors targeting PD-L1 for cancer immunotherapy
Blockade of the interaction between programmed cell death ligand-1 (PD-L1) and its
receptor PD-1 has shown great success in cancer immunotherapy. Peptides possess unique …
receptor PD-1 has shown great success in cancer immunotherapy. Peptides possess unique …
PD-1-targeted discovery of peptide inhibitors by virtual screening, molecular dynamics simulation, and surface plasmon resonance
The blockade of the programmed cell death protein 1/programmed cell death ligand 1 (PD-
1/PD-L1) pathway plays a critical role in cancer immunotherapy by reducing the immune …
1/PD-L1) pathway plays a critical role in cancer immunotherapy by reducing the immune …
Design and evaluation of α-helix-based peptide inhibitors for blocking PD-1/PD-L1 interaction
The current research in tumor immunotherapy indicates that blocking the protein-protein
interaction (PPI) between PD-1 and its ligand, PD-L1, may be one of the most effective …
interaction (PPI) between PD-1 and its ligand, PD-L1, may be one of the most effective …
Recruiting monomer for dimer formation: resolving the antagonistic mechanisms of novel immune check point inhibitors against programmed death ligand-1 in cancer …
The design of small molecule antagonists against Programmed Death Ligand-1 (PD-L1) has
been the recent highlight of the immune checkpoint blockade therapy. This interventive …
been the recent highlight of the immune checkpoint blockade therapy. This interventive …
PD-L1 inhibitors: different classes, activities, and mechanisms of action
E Surmiak, K Magiera-Mularz, B Musielak… - International Journal of …, 2021 - mdpi.com
Targeting the programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/PD-
L1) interaction has become an established strategy for cancer immunotherapy. Although …
L1) interaction has become an established strategy for cancer immunotherapy. Although …
Understanding the structural and energetic basis of PD-1 and monoclonal antibodies bound to PD-L1: A molecular modeling perspective
D Shi, S Zhou, X Liu, C Zhao, H Liu, X Yao - Biochimica et Biophysica Acta …, 2018 - Elsevier
Background The inhibitors blocking the interaction between programmed cell death protein
1 (PD-1) and programmed death-ligand 1 (PD-L1) can activate the immune response of T …
1 (PD-1) and programmed death-ligand 1 (PD-L1) can activate the immune response of T …
Molecular dynamics simulations elucidate conformational selection and induced fit mechanisms in the binding of PD-1 and PD-L1
Blockage of the interactions between immunologic checkpoint protein PD-1 and its ligand
PD-L1 showed efficacy for cancer treatment. X-ray structures have captured static …
PD-L1 showed efficacy for cancer treatment. X-ray structures have captured static …
[HTML][HTML] Peptide-based inhibitors targeting the PD-1/PD-L1 axis: potential immunotherapeutics for cancer
M Bojko, K Węgrzyn, E Sikorska, P Ciura, C Battin… - Translational …, 2024 - Elsevier
Abstract The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints
and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for …
and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for …
Investigating the role of the N-terminal loop of PD-1 in binding process between PD-1 and nivolumab via molecular dynamics simulation
W Liu, H Jin, T Chen, G Zhang, S Lai… - Frontiers in Molecular …, 2020 - frontiersin.org
The blockade of immune checkpoints, such as programmed death receptor 1 (PD-1) and
programmed death ligand 1 protein (PD-L1), is a promising therapeutic approach in cancer …
programmed death ligand 1 protein (PD-L1), is a promising therapeutic approach in cancer …
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