Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …

When dissolution testing is used to forecast the in vivo performance of a drug, it is critical that
the in vitro test mimic the conditions in vivo as closely as possible. A team of researchers, led …

Purpose The aim of this study was to update the compositions of biorelevant media to
represent the composition and physical chemical characteristics of the gastrointestinal fluids …

As part of a drive to develop predictive in vitro models to forecast the in vivo performance of
drugs and drug products, two biorelevant dissolution media simulating conditions in the …

Background Biorelevant media for evaluation of dosage form performance in the
gastrointestinal lumen were first introduced in the late 1990s. Since then, a variety of …

Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

Although several routes of administration can be considered for new drug entities, the most
popular remains the oral route. To predict the in vivo performance of a drug after oral …

Dissolution tests that can predict the in vivo performance of drug products are usually called
biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide …

Purpose. In this paper we seek to verify the differences in dissolution behavior between
class I and class II drugs and to evaluate the suitability of two new physiologically based …

The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …