In the mammalian brain, a family of sodium-dependent transporters maintains low
extracellular glutamate and shapes excitatory signaling. The bulk of this activity is mediated …

In addition to being an amino acid that is incorporated into proteins, glutamate is the most
abundant neurotransmitter in the mammalian CNS, the precursor for the inhibitory …

Efficient excitatory transmission depends on a family of transporters that use the Na+-
electrochemical gradient to maintain low synaptic concentrations of glutamate. These …

Astrocytes, the major glial cell type in the central nervous system (CNS), are critical for brain
function and have been implicated in various disorders of the central nervous system. These …

Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from
presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma …

High-affinity glutamate transporters ensure termination of glutamatergic neurotransmission
and keep the synaptic concentration of this amino acid below excitotoxic levels. However …

Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …

Glutamate, the main excitatory amino acid in the vertebrate brain, is critically involved in
most of the physiological functions of the central nervous system. It has traditionally been …

The activity of high‐affinity glutamate transporters is essential for the normal function of the
mammalian central nervous system. Using a combined pharmacological, confocal …

Glutamate transporters clear glutamate from the extracellular space by high-affinity binding
and uptake. Factors that regulate glutamate transporter expression and activity can thereby …