There exist limited data to inform mechanism-based understanding and management of
chronic pain, and thus, there is a clear unmet need to better define the molecular …

Pharmacological, surgical, psychological, and alternative medicine approaches for the
treatment of chronic pain, including neuropathic pain, provide only partial relief for most …

Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of
life and a higher risk of developing co-morbidities such as depression. Available treatments …

Chronic pain represents a major health burden; this maladaptive pain state occurs as a
consequence of hypersensitivity within the peripheral and central components of the …

Pain is the leading cause of disability worldwide, imposing an enormous burden on
personal health and society. Pain is a multifactorial and multidimensional problem …

The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …

Despite significant advances in our understanding of the molecular basis of pain, the precise
contributions of individual genes to our perception of this primal sensation remains …

Neuropathic pain (NeP) is initiated by a lesion or dysfunction in the nervous system. Unlike
physiological pain it serves no useful purpose and is usually sustained and chronic. NeP …

Pain is a fundamental and central life experience, a counterbalance to pleasure, a warning
of danger, and a reminder to guard injured limbs and tissues while they heal. And yet …

There is a critical need for effective new pharmacotherapies for pain. The paucity of new
drugs successfully reaching the clinic calls for a reassessment of current analgesic drug …