A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

LN Rapado, GC Freitas, A Polpo, M Rojas-Cardozo… - Molecules, 2014 - mdpi.com
The search of alternative compounds to control tropical diseases such as schistosomiasis
has pointed to secondary metabolites derived from natural sources. Piper species are …

Structure–Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian Cells

Y Campelo, A Ombredane, AG Vasconcelos… - International Journal of …, 2018 - mdpi.com
Schistosomiasis, caused by helminth flatworms of the genus Schistosoma, is an infectious
disease mainly associated with poverty that affects millions of people worldwide. Since …

Structure-based study of natural products with anti-schistosoma activity

I Akachukwu, OO Olubiyi… - … -Aided Drug Design, 2017 - ingentaconnect.com
Background: Schistosomiasis is a parasitic protozoal disease caused by flatworms of the
genus Schistosoma. Although the disease threatens millions of lives, it is still at the top list of …

In Silico Comparison of Bioactive Compounds Characterized from Azadirachta indica with an FDA-Approved Drug against Schistosomal Agents: New Insight into …

BE Oyinloye, DE Shamaki, EA Agbebi, SA Onikanni… - Molecules, 2024 - mdpi.com
The burden of human schistosomiasis, a known but neglected tropical disease in Sub-
Saharan Africa, has been worrisome in recent years. It is becoming increasingly difficult to …

In Silico Study of Cucurbita maxima Compounds as Potential Therapeutics Against Schistosomiasis

FL Mtemeli, R Shoko, J Ndlovu… - … and Biology Insights, 2022 - journals.sagepub.com
Schistosomiasis, a disease usually related to poverty and poor sanitation, affects more than
200 million people worldwide. Since the 1970s, the medical sector has depended on a …

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties

JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …

First in silico screening of insect molecules for identification of novel anti-parasitic compounds

TL Gallinger, SY Aboagye, W Obermann, M Weiss… - Pharmaceuticals, 2022 - mdpi.com
Schistosomiasis is a neglected tropical disease caused by blood flukes of the genus
Schistosoma. In silico screenings of compounds for the identification of novel anti-parasitic …

Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis

CM Azevedo, CS Meira, JW da Silva, DMN Moura… - Molecules, 2023 - mdpi.com
It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease
transmission is related to the poor sanitation and hygiene habits that affect residents of …

Synthesis, anti-schistosomal activity and molecular modeling of two novel 8-hydroxyquinoline derivatives

AF Eweas, G Allam, A SA Abu-Elsaad… - Anti-Infective …, 2013 - ingentaconnect.com
Schistosomiasis is one of the world's greatly neglected tropical diseases, and its control is
largely dependent on a single drug, praziquantel (PZQ). Here, two novel 8-hydroxyqinoline …

Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach

RYB Nugraha, IFD Faratisha… - BioMed Research …, 2020 - Wiley Online Library
Malaria is one of the life‐threatening diseases in the world. The spread of resistance to
antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in …