Tissue engineered heart valves offer a promising alternative for the replacement of diseased
heart valves avoiding the limitations faced with currently available bioprosthetic and …

The current clinical solutions, including mechanical and bioprosthetic valves for valvular
heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to …

It is estimated that the number of patients requiring heart valve replacement will triple over
the next five decades. None of the current replacement valves can fully restore native valve …

Introduction: Heart valve disease is an increasingly prevalent and clinically serious
condition. There are no clinically effective biological diagnostics or treatment strategies. The …

Tissue engineering of heart valves is an evolving research field. Driven by the shortcomings
of the heart valve substitutes currently available, such as need for anticoagulation …

Heart valve replacement is often the only solution for patients suffering from valvular heart
disease. However, currently available valve replacements require either life‐long …

The prevalence of valve disease is increasing worldwide. Given the need to reduce the
occurrence of complications experienced with mechanical and tissue valve replacements …

As the first section of a multi-part review series, this section provides an overview of the
ongoing research and development aimed at fabricating novel heart valve replacements …

Potential applications of tissue engineering in regenerative medicine range from structural
tissues to organs with complex function. This review focuses on the engineering of heart …

Opinion statement Heart valve disease is a major health burden, treated by either valve
repair or valve replacement, depending on the affected valve. Nearly 300,000 valve …