Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
YS Wang, TW Hung, EK Bae, KJ Wu… - CNS Neuroscience …, 2021 - Wiley Online Library
Aims Naltrexone is a mu opioid receptor (MOR) antagonist used to treat drug dependence in
patients. Previous reports indicated that MOR antagonists reduced neurodegeneration and …
patients. Previous reports indicated that MOR antagonists reduced neurodegeneration and …
Morphine attenuates neuroinflammation and blood-brain barrier disruption following traumatic brain injury through the opioidergic system
Endogenous opiates are suggested to have a role in the pathophysiology of traumatic brain
injury (TBI). Furthermore, administration of opioidergic agents in TBI injured animals have …
injury (TBI). Furthermore, administration of opioidergic agents in TBI injured animals have …
Naloxone exacerbates memory impairments and depressive-like behavior after mild traumatic brain injury (mTBI) in mice with upregulated opioid system activity
A Lesniak, P Leszczynski, M Bujalska-Zadrozny… - Behavioural brain …, 2017 - Elsevier
The neuroprotective role of the endogenous opioid system in the pathophysiological
sequelae of brain injury remains largely ambiguous. Noteworthy, almost no data is available …
sequelae of brain injury remains largely ambiguous. Noteworthy, almost no data is available …
β-Funaltrexamine displayed anti-inflammatory and neuroprotective effects in cells and rat model of stroke
CC Wu, CY Chang, KC Shih, CJ Hung… - International Journal of …, 2020 - mdpi.com
Chronic treatment involving opioids exacerbates both the risk and severity of ischemic
stroke. We have provided experimental evidence showing the anti-inflammatory and …
stroke. We have provided experimental evidence showing the anti-inflammatory and …
Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)
A Lesniak, CG Pick, A Misicka, AW Lipkowski… - …, 2016 - Elsevier
Traumatic brain injury (TBI) is often a result of traffic accidents, contact sports or battlefield
explosions. A mild form of traumatic brain injury (mTBI) is frequently underestimated, as the …
explosions. A mild form of traumatic brain injury (mTBI) is frequently underestimated, as the …
[HTML][HTML] Sex specific effects of buprenorphine on behavior, astrocytic opioid receptor expression and neuroinflammation after pediatric traumatic brain injury in mice
Y Hamood, M Abdullah, H El Ghoul, N Saad… - Brain, Behavior, & …, 2022 - Elsevier
Children who suffered traumatic brain injury (TBI) often experience acute and chronic pain,
which is linked to a poor quality of life. Buprenorphine (BPN) is commonly used to treat …
which is linked to a poor quality of life. Buprenorphine (BPN) is commonly used to treat …
Contusive spinal cord injury up regulates mu-opioid receptor (mor) gene expression in the brain and down regulates its expression in the spinal cord: possible …
FM Michael, AN Mohapatra, L Venkitasamy… - Neurological …, 2015 - Taylor & Francis
Traumatic spinal cord injury (SCI) is one of the dreaded neurological conditions and finding
a cure for it has been a hot area of research. Naloxone–a mu-opiate receptor (mor) …
a cure for it has been a hot area of research. Naloxone–a mu-opiate receptor (mor) …
δ-Opioid receptor activation rescues the functional TrkB receptor and protects the brain from ischemia-reperfusion injury in the rat
X Tian, J Guo, M Zhu, M Li, G Wu, Y Xia - PloS one, 2013 - journals.plos.org
Objectives δ-opioid receptor (DOR) activation reduced brain ischemic infarction and
attenuated neurological deficits, while DOR inhibition aggravated the ischemic damage. The …
attenuated neurological deficits, while DOR inhibition aggravated the ischemic damage. The …
Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury
CC Chen, TH Hung, YH Wang, CW Lin, PY Wang… - PloS one, 2012 - journals.plos.org
Background Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that
contributes to neuronal damage and behavioral impairment. This study was undertaken to …
contributes to neuronal damage and behavioral impairment. This study was undertaken to …
[HTML][HTML] Role of phosphodiesterase inhibitor Ibudilast in morphine-induced hippocampal injury
M Zhaleh, M Panahi, MG Broujerdnia… - Journal of Injury and …, 2014 - ncbi.nlm.nih.gov
Background: Opioid drugs are used in the treatment of acute post-surgical pain and chronic
pain, such as those associated with cancer. Opioid used is associated with complications …
pain, such as those associated with cancer. Opioid used is associated with complications …